April 1, 1995AJP Cell Physiology

Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor

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Why the study?

Does adenosine attenuate calcium paradox injury in isolated rat hearts?

Structured PICO

Does adenosine attenuate calcium paradox injury in isolated rat hearts?

Population

Isolated rat hearts subjected to calcium paradox (PD) injury

Intervention

Adenosine (dose-dependent, maximum at 100 microM) or adenosine A1 receptor agonist N6-phenylisopropyladenosine before and during Ca2+ PD

Comparator

Regular Ca2+ PD without adenosine

Outcome

Maximum lactate dehydrogenase release and ATP losssurrogate

Adenosine protects against calcium paradox injury in isolated rat hearts via A1 receptor activation and a pertussis toxin-sensitive inhibiting G protein.

Discussion

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Implication

Adenosine may attenuate calcium paradox injury in isolated rat hearts; leaves open translation to clinical cardioprotection.

Cite This Study

Suleiman et al. (1995) studied this question.

synapsesocial.com/papers/6a86c8f2a131ca67071546a5 https://doi.org/10.1152/ajpcell.1995.268.4.c838

View Full Paper

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Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor

Structured PICO

Discussion

Implication

Cite This Study

Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider