Why the study?
Does propranolol therapy throughout pregnancy affect maternal and fetal outcomes in a patient with early-gestation cardiac arrest?
Does propranolol therapy throughout pregnancy affect maternal and fetal outcomes in a patient with early-gestation cardiac arrest?
Propranolol use throughout pregnancy may lead to fetal growth retardation and poor tolerance of labor due to beta-adrenergic blockade.
Answers are grounded in this paper and cite their sources.
Propranolol in pregnancy warrants fetal monitoring or avoidance; case report leaves open risk-benefit after early-gestation cardiac arrest.
The course of pregnancy and delivery of a patient who suffered cardiac arrest and required resuscitation in the 1st weeks of gestation, and who was treated with propranolol for the remainder, is described. Propranolol blocks responses to the hemodynamic demands placed on the pregnant woman's circulation, blocks fetal responses to the stresses of labor and delivery, and extends into the neonatal period. The beta-adrenergic-blocked fetus may be expected to show growth retardation and to tolerate labor poorly.
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Reed et al. (1974) studied this question.
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