Why the study?
Does propranolol affect hemodynamics and premature systoles in patients with complete heart block and fixed rate pacemakers?
Population
10 patients with complete heart block and fixed rate internal pacemakers, grouped by the absence or presence…
Comparison
Propranolol (beta-adrenergic blockade) vs Baseline (before propranolol was given)
Design
Case_series
Authors
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May warrant caution in fixed-rate paced patients; leaves open effects of modern beta-blockers or variable-rate pacing.
Does propranolol affect hemodynamics and premature systoles in patients with complete heart block and fixed rate pacemakers?
Propranolol exerts a significant negative inotropic effect independent of its chronotropic effect, as demonstrated by decreased cardiac output and contractility in patients with fixed-rate pacemakers.
Donoso et al. (1967) studied this question.
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