What question did this study set out to answer?

To assess the hemodynamic impact of intravenous propranolol in patients with complete atrioventricular heart block maintained at a constant paced heart rate.

January 12, 1968Acta Medica Scandinavica

HEMODYNAMIC EFFECTS OF βADRENERGIC BLOCKADE IN PATIENTS WITH COMPLETE HEART BLOCK AND IMPLANTED PACEMAKER

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Why the study?

Does intravenous propranolol alter hemodynamic performance in patients with complete heart block and implanted pacemakers at a constant ventricular rate?

Population

9 patients with complete atrioventricular heart block undergoing permanent endocardial pacing with a…

Design

Case_series

Authors

PLPer G. Lund‐LarsenOslo University Hospital ESE SivertssenOslo University Hospital ELE LorentsenOslo University Hospital

Discussion

Member takes

Implication

Supports isolated ventricular inotropy reduction with IV propranolol at fixed rates; leaves open confirmation in controlled studies.

Key Points

To assess the hemodynamic impact of intravenous propranolol in patients with complete atrioventricular heart block maintained at a constant paced heart rate.
Administered 5 mg of intravenous propranolol to 9 patients with complete atrioventricular heart block during permanent endocardial pacing.
Held heart rate constant using preset pacemaker frequency while recording cardiac output, maximal arterial dp/dt, and maximal atrial systolic pressure.
Cardiac output decreased in all 9 patients and maximal arterial dp/dt fell consistently following propranolol administration.
Atrial retardation developed in all patients, whereas atrial contractility was preserved as indicated by stable maximal atrial systolic pressure.

Structured PICO

Does intravenous propranolol alter hemodynamic performance in patients with complete heart block and implanted pacemakers at a constant ventricular rate?

Population

9 patients with complete atrioventricular heart block undergoing permanent endocardial pacing with a constant preset pacemaker frequency

Intervention

Propranolol 5 mg intravenously

Outcome

Hemodynamic effects including cardiac output, maximal arterial dp/dt, atrial retardation, and atrial contractility (maximal atrial systolic pressure)surrogate

Intravenous propranolol reduces cardiac performance in patients with a fixed ventricular rate solely through its negative inotropic effect on the ventricular myocardium.

Cite This Study

Lund‐Larsen et al. (1968) studied this question.

synapsesocial.com/papers/6a8ba9759d5fb440a3beb293 https://doi.org/10.1111/j.0954-6820.1968.tb10515.x

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HEMODYNAMIC EFFECTS OF βADRENERGIC BLOCKADE IN PATIENTS WITH COMPLETE HEART BLOCK AND IMPLANTED PACEMAKER

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

HEMODYNAMIC EFFECTS OF βADRENERGIC BLOCKADE IN PATIENTS WITH COMPLETE HEART BLOCK AND IMPLANTED PACEMAKER

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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