Key result
Oral propranolol produced identical blockade effects on the sinus and atrioventricular nodes that persisted >24 hours despite undetectable plasma levels, with transient hypersensitivity at 36-48 hours.
Why the study?
What is the time course of the blockade effect of propranolol on the sinus and atrioventricular nodes in normal volunteers?
Population
6 normal volunteers
Comparison
Oral propranolol 160 mg daily for two days vs Baseline (before propranolol administration)
Design
Other
Follow-up
48 hours after propranolol withdrawal
Authors
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Prolonged nodal blockade may inform propranolol withdrawal caution; leaves open confirmation in larger patient cohorts.
What is the time course of the blockade effect of propranolol on the sinus and atrioventricular nodes in normal volunteers?
Propranolol exerts a prolonged blockade on the sinus and atrioventricular nodes that outlasts its detectable presence in plasma, followed by a transient hypersensitivity upon withdrawal.
Boudoulas et al. (1979) studied normal volunteers (n=6). Propranolol vs. Baseline (before propranolol administration) was evaluated on Blockade effect on the sinus node and the atrioventricular node. Oral propranolol produced identical blockade effects on the sinus and atrioventricular nodes that persisted >24 hours despite undetectable plasma levels, with transient hypersensitivity at 36-48 hours.
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