Why the study?
Does acute propranolol injection alter haemodynamics and uteroplacental blood flow in hypertensive pregnant rats?
Does acute propranolol injection alter haemodynamics and uteroplacental blood flow in hypertensive pregnant rats?
Acute propranolol administration in hypertensive pregnant rats lowers blood pressure via reduced cardiac output but severely compromises uteroplacental blood flow.
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Raises concern for uteroplacental compromise with acute propranolol in hypertensive pregnancy models; leaves open human translation.
Karlsson et al. (1984) studied this question.