Why the study?
Does oral infection with coxsackievirus B3 in pregnant mice cause perinatal transmission and mortality?
Population
Pregnant mice late in gestation
Design
Preclinical
Follow-up
Up to 10 days post-infection and postnatal period
Authors
Loading...
Maternal late-gestation CVB3 infection may drive perinatal mortality without fetal infection; hypothesis-generating for human pregnancy outcomes.
Does oral infection with coxsackievirus B3 in pregnant mice cause perinatal transmission and mortality?
Maternal coxsackievirus B3 infection late in gestation leads to significant stillbirth and postnatal mortality in mice, despite low rates of direct fetal infection.
Modlin et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: