Why the study?
Are polymorphisms of genes encoding components of the sympathetic nervous system and renin-angiotensin system associated with orthostatic hypotension in community-dwelling older adults?
Are polymorphisms of genes encoding components of the sympathetic nervous system and renin-angiotensin system associated with orthostatic hypotension in community-dwelling older adults?
Polymorphisms in genes encoding sympathetic nervous system components (GNAS1 and GNB3), but not the renin-angiotensin system, are associated with an increased risk of orthostatic hypotension in older adults.
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May increase orthostatic hypotension risk in older adults; hypothesis-generating and should not yet change practice.
Tabara et al. (2002) studied this question.
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