Key result
X-ray diffraction experiments on striated muscle reveal structural changes during contraction that support a 'roll and lock' model where initial stereo-specific locking of myosin heads on actin precedes the lever arm tilt.
Population
Striated muscle (including rabbit, frog, and fish fin muscle fibers)
Design
Review
Loading...
Refines the lever-arm model of sarcomere force generation; extends structural insights but leaves applicability to cardiac muscle open.
X-ray diffraction studies of striated muscle support a 'roll and lock' model of force generation, refining the widely accepted lever arm hypothesis.
A 2009 study reported a review. X-ray diffraction experiments on striated muscle reveal structural changes during contraction that support a 'roll and lock' model where initial stereo-specific locking of myosin heads on actin precedes the lever arm tilt.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: