June 1, 1993Circulation Research

High alpha 1-adrenoceptor occupancy decreases relaxing potency of nifedipine by increasing myosin light chain phosphorylation.

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Population

Isolated strips of rabbit renal arteries

Comparison

Phenylephrine at 1 microM and 100 microM… vs Different concentrations of phenylephrine

Design

Preclinical

Authors

PRPaul H. RatzVirginia Commonwealth University

Discussion

Member takes

Implication

Nifedipine potency may vary with α1-occupancy in vessels; leaves open translation of receptor reserve to clinical CCB use.

Structured PICO

Population

Isolated strips of rabbit renal arteries

Intervention

Phenylephrine (PhE) at 1 microM and 100 microM, followed by nifedipine (0.1 microM)

Comparator

Different concentrations of phenylephrine (1 microM vs 100 microM)

Outcome

Myosin light chain phosphorylation and vascular stresssurrogate

High alpha 1-adrenoceptor occupancy decreases the relaxing potency of nifedipine because spare receptors increase myosin light chain phosphorylation beyond the level required for maximum stress.

Cite This Study

Paul H. Ratz (1993) studied this question.

synapsesocial.com/papers/6a86daefddd5671cb07cb88e https://doi.org/10.1161/01.res.72.6.1308

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High alpha 1-adrenoceptor occupancy decreases relaxing potency of nifedipine by increasing myosin light chain phosphorylation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High alpha 1-adrenoceptor occupancy decreases relaxing potency of nifedipine by increasing myosin light chain phosphorylation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider