July 1, 1980HypertensionOpen Access

Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects.

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Population

Normal and hypertensive human subjects

Design

Cross-sectional

Authors

TITakashi ItoKyushu University PEPeter EggenaUniversity of California, Los Angeles JBJack BarrettSouth Western Ambulance Service NHS Foundation Trust

Discussion

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Implication

Distinguishes central from peripheral angiotensinogen in hypertension; hypothesis-generating for brain RAS role, needs prospective validation.

Structured PICO

Population

Normal and hypertensive human subjects

Comparator

Normotensive subjects

Outcome

Immunological and physical-chemical nature of angiotensinogen in plasma and cerebrospinal fluid (CSF), and angiotensinogen concentrationssurrogate

Differences in the chemical and immunological nature of human plasma and CSF angiotensinogens suggest that CSF angiotensinogen is not of peripheral origin, and concentrations differ between normotensive and hypertensive subjects.

Cite This Study

Ito et al. (1980) studied this question.

synapsesocial.com/papers/6a86de08540b033b21bef71a https://doi.org/10.1161/01.hyp.2.4.432

Topics

Hypertension management

View Full Paper

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Implication

Distinguishes central from peripheral angiotensinogen in hypertension; hypothesis-generating for brain RAS role, needs prospective validation.

Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider