Key result
Persistent use of ≥3 heart failure medications was associated with an 80% decrease in hospitalizations and a 70% decrease in total costs compared to no therapy (p≤0.001).
Why the study?
Does concurrent and persistent use of heart failure medications reduce hospitalizations and costs in patients with heart failure?
Population
1,903 patients with heart failure enrolled in a managed care organization within the US.
Comparison
Concurrent and persistent use of heart failure… vs No use of the 4 studied heart failure agents.
Design
Cohort
Follow-up
1 year
Authors
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May support emphasis on persistent multi-drug GDMT in HF; leaves open causality and practice change pending randomized confirmation.
Observational (n=1,903)
Does concurrent and persistent use of heart failure medications reduce hospitalizations and costs in patients with heart failure?
Effect estimate: 80% decrease
p-value: p=≤0.001
Persistent use of multiple guideline-directed heart failure medications significantly reduces hospitalizations and healthcare costs in real-world practice.
Skrepnek et al. (2005) conducted an observational in heart failure (n=1,903). Persistent use of ≥3 heart failure medications (ACE inhibitors, beta-blockers, loop diuretics, digoxin) vs. No heart failure therapy was evaluated on One-year all-cause hospitalization (80% decrease, p=≤0.001). Persistent use of ≥3 heart failure medications was associated with an 80% decrease in hospitalizations and a 70% decrease in total costs compared to no therapy (p≤0.001).
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