Why the study?
Does a history of NPH insulin use increase the risk of major adverse reactions to protamine in patients undergoing cardiac catheterization?
Population
651 consecutive patients undergoing cardiac catheterization who received protamine for reversal of…
Comparison
History of NPH insulin use vs No history of NPH insulin use
Design
Cohort
Follow-up
Immediate post-administration
Authors
Loading...
NPH insulin use was associated with higher protamine reaction rates; this Level 3 finding leaves open whether avoidance is warranted pending prospective confirmation.
Does a history of NPH insulin use increase the risk of major adverse reactions to protamine in patients undergoing cardiac catheterization?
NPH insulin-dependent diabetics have a 50-fold increased risk of major adverse reactions to protamine during cardiac catheterization, suggesting protamine should be avoided or used with extreme caution in this population.
Stewart et al. (1984) studied this question.