Why the study?
What are the adverse reactions to protamine sulfate and are alternatives needed?
What are the adverse reactions to protamine sulfate and are alternatives needed?
Protamine sulfate can cause severe adverse reactions, including fatal anaphylaxis, particularly in patients previously exposed through protamine-containing insulins or prior heparin neutralization.
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Alerts clinicians to fatal protamine anaphylaxis risk on re-exposure; leaves open need for alternatives and prospective risk studies.
Weiler et al. (1985) studied this question.
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