Key result
An isolated rat heart model of low-flow ischemia exhibited clinical characteristics of hibernating myocardium, including flow-metabolism mismatch with increased 18FDG6P accumulation (P<0.05).
Absolute Event Rate: 0.023% vs 0.011%
p-value: p=<0.05
An isolated rat heart model of acute low-flow ischemia successfully replicates clinical hallmarks of hibernating myocardium, providing a platform for further experimental study.
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Offers rat heart model for hibernating myocardium studies; leaves open clinical translation pending further validation.
Southworth et al. (2003) studied Hibernating myocardium. Low-flow ischemia vs. Control tissue (100% flow) was evaluated on 18FDG6P accumulation (glucose + oleate) (p=<0.05). An isolated rat heart model of low-flow ischemia exhibited clinical characteristics of hibernating myocardium, including flow-metabolism mismatch with increased 18FDG6P accumulation (P<0.05).
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