Assessment of cerebral injury with spinal fluid creatine kinase (CSF-CK) in patients after cardiac resuscitation

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Why the study?

Does spinal fluid creatine kinase (CSF-CK) level predict cerebral injury and recovery in patients comatose after cardiac resuscitation?

Population

82 patients comatose after cardiac resuscitation because of ventricular fibrillation

Design

Cohort

Authors

Discussion

High CSF-CK activity after successful cardiac resuscitation effectively predicts an unfavorable neurological outcome of global cerebral ischemia.

Does spinal fluid creatine kinase (CSF-CK) level predict cerebral injury and recovery in patients comatose after cardiac resuscitation?

Population

82 patients comatose after cardiac resuscitation because of ventricular fibrillation

Intervention

Serial determinations of creatine kinase in cerebrospinal fluid (CSF-CK)

Outcome

Cerebral recovery/outcome (unconsciousness, permanent cerebral dysfunction, or complete cerebral restitution)surrogate

High CSF-CK activity after successful cardiac resuscitation effectively predicts an unfavorable neurological outcome of global cerebral ischemia.

Kjekshus et al. (1980) studied this question.

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High CSF-CK activity after successful cardiac resuscitation effectively predicts an unfavorable neurological outcome of global cerebral ischemia.