Why the study?
Does total creatine kinase activity in cerebrospinal fluid correlate with irreversible neuronal damage in patients undergoing open-heart surgery?
Does total creatine kinase activity in cerebrospinal fluid correlate with irreversible neuronal damage in patients undergoing open-heart surgery?
Total creatine kinase activity in cerebrospinal fluid correlates with irreversible neuronal damage during open-heart surgery and may have prognostic value.
CSF CK may mark neuronal injury severity after cardiac surgery; hypothesis-generating for prognosis, needs prospective validation before any clinical role.
In a selected series of 33 patients undergoing open-heart surgery, the creatine kinase (CK) activity in cerebrospinal fluid (CSF) was compared with the clinical results in regard to the central nervous system. The level of CK activity in CSF showed correlation with the degree of irreversible neuronal damage. Determination of CK in CSF may thus be of prognostic value in these patients. Caution is essential, however, in the setting of strict limits above which return to normal or acceptable quality of life is not to be expected.
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Lundar et al. (1983) studied this question.
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