September 1, 2001European Journal of Emergency Medicine

Creatinine-kinase-MB determination in non-cardiac trauma: its difference with cardiac infarction and its restricted use in trauma situations

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Why the study?

Does CK-MB determination accurately identify cardiac injury in trauma patients?

Population

116 trauma patients, comprising 25 with only skeletal muscle injury and 91 consecutive patients with severe…

Comparison

Creatine-kinase-MB isoenzyme level determination… vs Comparison between patients with skeletal muscle…

Design

Cohort

Follow-up

4 days

Authors

MRMartin RuppertAkershus University Hospital RHR. Van HeeUniversity of Antwerp

Discussion

Member takes

Implication

CK-MB positivity after skeletal trauma cautions against its use to diagnose cardiac contusion; leaves open validation of troponin or imaging in prospective cohorts.

Structured PICO

Does CK-MB determination accurately identify cardiac injury in trauma patients?

Population

116 trauma patients, comprising 25 with only skeletal muscle injury and 91 consecutive patients with severe chest injury (including 10 with cardiac complications).

Intervention

Creatine-kinase-MB (CK-MB) isoenzyme level determination from blood samples taken during the first 4 days after trauma.

Comparator

Comparison between patients with skeletal muscle injury only and patients with severe chest injury (with and without cardiac complications).

Outcome

Course of CK/CK-MB release and its diagnostic accuracy for cardiac injury.surrogate

CK-MB testing is frequently positive in trauma patients without cardiac injury due to skeletal muscle release, rendering it an unreliable screening tool for cardiac contusion.

Cite This Study

Ruppert et al. (2001) studied this question.

synapsesocial.com/papers/6a901bd8fdaee66aea84001e https://doi.org/10.1097/00063110-200109000-00003

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Implication

CK-MB positivity after skeletal trauma cautions against its use to diagnose cardiac contusion; leaves open validation of troponin or imaging in prospective cohorts.

Creatinine-kinase-MB determination in non-cardiac trauma: its difference with cardiac infarction and its restricted use in trauma situations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Creatinine-kinase-MB determination in non-cardiac trauma: its difference with cardiac infarction and its restricted use in trauma situations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider