Why the study?
Does dilution of total CK activity prevent false positive CK-MB detection in patients with alcoholic rhabdomyolysis?
Does dilution of total CK activity prevent false positive CK-MB detection in patients with alcoholic rhabdomyolysis?
High total CK concentrations from skeletal muscle injury can cause false-positive CK-MB results, which can be corrected by sample dilution.
Answers are grounded in this paper and cite their sources.
May avoid false-positive CK-MB by diluting high total CK samples in rhabdomyolysis; hypothesis-generating and needs prospective validation.
The MG isoenzyme of creatine kinase (CK MB) was strongly positive in the serum of a patient with alcoholic rhabdomyolysis, and it remained detectable by a standard qualitative assay over a two-year period without clinical or laboratory evidence of myocardial disease. MB isoenzyme was also demonstrated in a homogenate of skeletal muscle. Isoenzyme determinations in serum and tissue were repeated after dilution of toal CK activity to the range optimal for the assay (300 IU/L). Such dilution before isoenzyme separation rendered these samples negative for CK MB. The MB isoenzyme may be detectable in serum from peripheral sources in the presence of high total CK concentrations.
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Arthur J. Siegel (1980) studied this question.
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