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October 1, 1996Anesthesia & Analgesia

Awakening, Clinical Recovery, and Psychomotor Effects After Desflurane and Propofol Anesthesia

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Why the study?

Does desflurane maintenance improve awakening and psychomotor recovery compared to propofol maintenance in volunteers?

Population

20 volunteers

Comparison

Desflurane maintenance for 1 hour vs Propofol maintenance for 1 hour

Design

RCT

Follow-up

7 hours

Authors

JAJeffrey L. ApfelbaumTulane UniversityJLJ. Lance LichtorYale UniversityBLBradford S. LaneUniversity of Chicago

Discussion

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Implication

Desflurane may accelerate early psychomotor recovery versus propofol without affecting discharge time; extends RCT evidence favoring volatiles for ambulatory anesthesia.

Structured PICO

Does desflurane maintenance improve awakening and psychomotor recovery compared to propofol maintenance in volunteers?

P
Population
20 volunteers
I
Intervention
Desflurane maintenance (propofol induction + desflurane in O2, propofol induction + desflurane in N2O-O2, or desflurane induction + desflurane in O2) for 1 hour
C
Comparator
Propofol maintenance (propofol induction + propofol infusion with N2O-O2) for 1 hour
O
Outcome
Awakening, clinical recovery (time to home readiness), and psychomotor skills (attention, coordination, reactive skills, and memory) up to 7 hours post-anesthesiasurrogate

Desflurane maintenance allows for faster early psychomotor recovery up to 1 hour post-anesthesia compared to propofol, though time to home readiness is similar.

Cite This Study

Apfelbaum et al. (1996) studied this question.

synapsesocial.com/papers/6a86edbf9749833e6e15495ehttps://doi.org/10.1213/00000539-199610000-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction and recovery characteristics of desflurane in day case patients: A comparison with propofol1991 · 108 citations
  2. 2Clinical Recovery and Psychomotor Function after Brief Anesthesia with Propofol or Thiopental1992 · 96 citations
  3. 3Recovery Profile After Desflurane With or Without Ondansetron Compared With Propofol in Patients Undergoing Outpatient Gynecological Laparoscopy1996 · 117 citations
  4. 4Objective and Subjective Impairment from Often-Used Sedative/Analgesic Combinations in Ambulatory Surgery, Using Alcohol as a Benchmark1995 · 40 citations
  5. 5Subjective and Psychomotor Effects of Sub anesthetic Doses of Propofol in Healthy Volunteers1992 · 93 citations