Key result
Primary cardiac B-cell lymphoma can destroy the sinus node structure and present as sick sinus syndrome, rapidly progressing to superior vena cava syndrome.
Case Report (n=1)
Primary cardiac B-cell lymphoma is a rare infiltrative cause of sick sinus syndrome that can present with rapid clinical deterioration.
Alerts clinicians to lymphoma in atypical progressive sinus node disease; leaves open need for series on incidence and management.
Sick sinus syndrome generally occurs in elderly patients. Two major causes for sick sinus syndrome are fibrosis of the sinus node and surrounding atrial myocardium and external causes to suppress the sinus node function. Fibrosis is mainly age-related, but can be caused by surgery, infiltrative diseases, or congenital disorders. We experienced a patient who presented with sick sinus syndrome and rapidly developed superior vena cava (SVC) syndrome shortly after the pacemaker implant. Autopsy showed B-cell lymphoma destroying the sinus node structure, which was thought to be the cause of sinus node dysfunction.
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Mohri et al. (2020) conducted a case report in Sick sinus syndrome and primary cardiac B-cell lymphoma (n=1). Primary cardiac B-cell lymphoma was evaluated on Cause of sinus node dysfunction. Primary cardiac B-cell lymphoma can destroy the sinus node structure and present as sick sinus syndrome, rapidly progressing to superior vena cava syndrome.
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