Key result
Physiological HbA1c levels were significantly correlated with pulse wave velocity (p=0.044) in non-diabetic, non-dialysis dependent chronic kidney disease patients.
Why the study?
The relationship between physiological levels of HbA1c and arterial stiffness is less clear in patients with chronic kidney disease without diabetes mellitus.
Cross-Sectional (n=51)
No
p-value: p=0.044
Physiological HbA1c levels are significantly correlated with arterial stiffness in non-diabetic, non-dialysis dependent chronic kidney disease patients.
HbA1c within physiological range was associated with arterial stiffness in non-diabetic CKD; hypothesis-generating and requires prospective trials before guiding targets.
BACKGROUND: Cardiovascular events are seen more frequently after the age of 60 and they are a significant cause of morbidity and mortality. Arterial stiffness is a property that can be expressed by pulse wave velocity and this value is assumed to be a predictor of cardiovascular events. Patients with chronic kidney disease and dysregulated blood sugar have increased atherosclerosis and arterial stiffness, but the relationship between physiological levels of Hba1c and arterial stiffness is less clear in chronic kidney disease patients without diabetes mellitus. OBJECTIVES: Here, we aimed to investigate the degree of arterial stiffness among non-diabetic, non-dialysis dependent chronic kidney disease patients with physiological HbA1c levels. METHODS: We enrolled 51 patients who were followed up at Ege University Hospital Nephrology Department between February and June 2015. Non-diabetic, non-dialysis dependent chronic kidney disease patients were included in the study. Blood pressure and pulse wave velocity were measured with an applanation tonometry device (Sphygmocor Vx Software Atcor Medical, Australia). Correlations between pulse wave velocity and the aforementioned parameters were investigated (see below). RESULTS: We detected a significant correlation between pulse wave velocity and systolic blood pressure (p=0.0001) and Hba1c (p=0.044) separately. There was an inverse correlation with creatinine clearance (p=0.04). We also detected a significant correlation with serum phosphorus level (p=0.0077) and furosemide use (p=0.014). No correlations were found among the other parameters. CONCLUSIONS: Arterial stiffness is an important predictor of cardiovascular events and measuring it is an inexpensive method for estimating morbidity and mortality. Our study supports the importance of measuring arterial stiffness and of controlling blood glucose levels, even at physiological Hba1c values, especially for chronic kidney disease patients.
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Turgutkaya et al. (2021) conducted a cross-sectional in Chronic kidney disease (n=51). HbA1c was evaluated on Pulse wave velocity (p=0.044). Physiological HbA1c levels were significantly correlated with pulse wave velocity (p=0.044) in non-diabetic, non-dialysis dependent chronic kidney disease patients.
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