Population
Seven isolated cat papillary muscles
Comparison
Ethrane with changes in time interval of… vs Control value
Design
Preclinical
Authors
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Ethrane's frequency-dependent contractility effects in isolated muscle warrant caution during tachycardia; leaves open translation to human perioperative myocardium.
Ethrane depresses myocardial contractility in isolated cat papillary muscles, but the muscle's ability to respond to changes in stimulation frequency is maintained.
Iwatsuki et al. (1970) studied this question.
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