December 1, 1989AJP Heart and Circulatory Physiology
Endocardium modulates myocardial inotropic response to 5-hydroxytryptamine
Population
Isolated cat papillary muscles
Comparison
5-hydroxytryptamine (5-HT, 0.01-30 microM) vs Endocardium-intact versus endocardium-damaged…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Endocardial integrity may modulate 5-HT effects on myocardial relaxation in animal models; hypothesis-generating and leaves open in vivo or clinical relevance.
Structured PICO
P
Population
Isolated cat papillary muscles
I
Intervention
5-hydroxytryptamine (5-HT, 0.01-30 microM)
C
Comparator
Endocardium-intact (+E) versus endocardium-damaged (-E, by 1-s immersion in 1% Triton X-100) preparations
O
Outcome
Half-isometric relaxation time (RT1/2), isometric twitch tension (TT), and maximum unloaded shortening velocity (Vmax)surrogate
The endocardium modulates the myocardial inotropic response to 5-HT, mediating an inhibitory effect that causes earlier isometric relaxation.
Cite This Study
Shah et al. (1989) studied this question.