Key result
In mesenteric small arteries from ZDF rats, 1 microM NS309 restored attenuated ACh-induced EDHF-type relaxation without changing endothelial intracellular calcium concentration.
Why the study?
Does NS309 restore EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats?
Population
Mesenteric small arteries from 21-week-old Zucker lean (ZL) and Zucker diabetic fatty (ZDF) rats
Comparison
NS309 and/or selective blockers of SK and IK… vs Arteries from Zucker lean rats, or untreated…
Design
Preclinical
Authors
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May identify NS309 as a target for diabetic endothelial dysfunction; hypothesis-generating from ZDF rat data and requires human validation.
Does NS309 restore EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats?
NS309 restores attenuated EDHF-type relaxation in mesenteric small arteries from type 2 diabetic rats, highlighting a potential therapeutic target for endothelial dysfunction.
Brøndum et al. (2009) studied Type 2 diabetes (animal model). NS309 vs. Zucker lean rats / absence of NS309 was evaluated on ACh-induced relaxation and membrane hyperpolarization. In mesenteric small arteries from ZDF rats, 1 microM NS309 restored attenuated ACh-induced EDHF-type relaxation without changing endothelial intracellular calcium concentration.
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