Key result
Three weeks of statin treatment in pigs did not significantly alter percent recovery of regional ventricular function after ischemia-reperfusion compared to control (e.g., atorvastatin 24% vs control 36%).
Why the study?
Do statins affect ventricular recovery and coronary vasodilation following ischemia-reperfusion in a porcine model?
Population
Farm pigs (n=23)
Comparison
Chow supplemented with atorvastatin… vs No statin (control) for 3 weeks
Design
Preclinical
Follow-up
3 weeks
Authors
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Statin pretreatment did not impair post-ischemic ventricular recovery in pigs but augmented coronary vasodilation; leaves open human translation.
Do statins affect ventricular recovery and coronary vasodilation following ischemia-reperfusion in a porcine model?
In a porcine model, 3-week statin treatment did not impair myocardial recovery from ischemia-reperfusion but augmented endothelium-dependent vasodilation of coronary conductance vessels.
Rendig et al. (2003) studied Myocardial ischemia-reperfusion (n=23). Statins (atorvastatin, pravastatin, simvastatin) vs. no statin (control) was evaluated on percent recovery of regional ventricular function at 30 min reperfusion. Three weeks of statin treatment in pigs did not significantly alter percent recovery of regional ventricular function after ischemia-reperfusion compared to control (e.g., atorvastatin 24% vs control 36%).
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