Key result
Egr-1 deletion in mice prolonged action potentials, reduced sarcoplasmic reticulum calcium content, and altered expression of calcium-handling proteins compared to wild-type littermates.
Population
Isolated left ventricular cardiomyocytes from Egr-1 knock-out (Egr-1(-/-)) homozygous mice
Comparison
Egr-1 gene deletion vs Wild-type (WT) littermates
Design
Preclinical
Authors
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Egr-1 emerges as a regulator of cardiac calcium handling in mice; hypothesis-generating for human arrhythmia mechanisms, should not yet change practice.
Egr-1 plays a pivotal role in regulating excitation-contraction coupling and calcium regulation in cardiac myocytes.
Pacini et al. (2013) studied Egr-1 deletion effects on cardiac function. Egr-1 deletion (Egr-1(-/-) homozygous mice) vs. Wild-type (WT) littermates was evaluated on Electrophysiological and molecular properties of left ventricular cardiomyocytes. Egr-1 deletion in mice prolonged action potentials, reduced sarcoplasmic reticulum calcium content, and altered expression of calcium-handling proteins compared to wild-type littermates.
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