Key result
Calcium channel blockers reduce myocardial injury and Egr-1 expression in rat ischemia-reperfusion models.
Why the study?
The potential role of Egr-1 as a target of calcium channel blockers in cardioprotection against ischemia/reperfusion injury was investigated.
Do calcium channel blockers reduce myocardial injury and Egr-1 expression in rat models of ischemia/reperfusion injury?
Population
Rats in vivo I/R models and rat cultured cardiomyocytes in vitro H/R models
Comparison
Calcium channel blockers (verapamil, diltiazem, nifedipine) vs no treatment
Design
Preclinical experimental study
Authors
Loading...
Supports Egr-1 as CCB target in rat I/R models; leaves open human translation.
Do calcium channel blockers reduce myocardial injury and Egr-1 expression in rat models of ischemia/reperfusion injury?
Calcium channel blockers may exert cardioprotective effects against ischemia/reperfusion injury by downregulating Egr-1 expression in preclinical models.
Huang et al. (2009) studied Ischemia/reperfusion injury. Calcium channel blockers (verapamil, diltiazem, nifedipine) was evaluated on Myocardial injury and inflammation (CK, LDH, SOD, MDA, MPO) and Egr-1 expression. Calcium channel blockers significantly attenuated myocardial injury and reduced Egr-1 expression in rat models of ischemia/reperfusion injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: