Key result
Active anticoagulation use was independently associated with a reduced incidence of pulmonary embolism on CTPA (OR 0.26) among emergency department patients evaluated for suspected pulmonary embolism.
Why the study?
The diagnostic yield of CTPA in screening for PE among patients presenting to the emergency department on active oral anticoagulation has not been well characterized.
Does active oral anticoagulation reduce the diagnostic yield of pulmonary embolism on CTPA in patients presenting to the emergency department with suspected PE?
Cohort (n=2,846)
No
Does active oral anticoagulation reduce the diagnostic yield of pulmonary embolism on CTPA in patients presenting to the emergency department with suspected PE?
Odds Ratio: 0.26 (95% CI 0.15–0.45)
p-value: p=<0.001
Patients presenting to the emergency department with suspected pulmonary embolism who are already on anticoagulation for non-VTE indications have a significantly lower diagnostic yield on CTPA, suggesting anticoagulation status should be incorporated into clinical risk stratification algorithms.
No takes yet. Share an insight, caveat, or question.
Lower CTPA yield on AC for non-VTE indications may inform ED testing thresholds; leaves open whether AC status should modify diagnostic algorithms.
Chatta et al. (2024) conducted a cohort in Suspected pulmonary embolism (n=2,846). Active oral anticoagulation vs. No active oral anticoagulation was evaluated on Incidence of pulmonary embolism on CTPA (OR 0.26, 95% CI 0.15-0.45, p=<0.001). Active anticoagulation use was independently associated with a reduced incidence of pulmonary embolism on CTPA (OR 0.26) among emergency department patients evaluated for suspected pulmonary embolism.
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