Why the study?
Does pulmonary microvascular injury or lung hyperinflation change left ventricular performance in an anesthetized dog model?
Population
7 open-chest, closed-pericardium, anesthetized dogs
Comparison
Right ventricular injections of 150- to… vs Basal state (before injury and hyperinflation)
Design
Preclinical
Authors
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Supports preload dependence of LV performance in this canine model; leaves open translation to human lung injury.
Does pulmonary microvascular injury or lung hyperinflation change left ventricular performance in an anesthetized dog model?
In a canine model, pulmonary microvascular injury and lung hyperinflation do not independently depress LV systolic performance beyond changes mediated by end-diastolic heart size (Starling mechanism).
Calvin et al. (1986) studied this question.
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