Why the study?
Does unilateral lung hyperinflation reflexly depress cardiovascular function in dogs?
Population
20 mongrel dogs of either sex, weighing 16-25 kg.
Comparison
Unilateral lung hyperinflation to 30 cm H2O… vs Pre-inflation control conditions and…
Design
Preclinical
Follow-up
15 minutes
Authors
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Should not alter ventilatory strategies; leaves open vagal mediation of hemodynamic effects in humans.
Does unilateral lung hyperinflation reflexly depress cardiovascular function in dogs?
Unilateral lung hyperinflation reflexly depresses heart rate, stroke volume, and blood pressure in dogs, an effect mediated primarily by vagal afferents from the inflated lung.
Cassidy et al. (1979) studied this question.
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