Why the study?
Does inflation of the lungs to a positive pressure of 20 mm Hg produce reflex cardiovascular depression in dogs?
Population
Dogs (experimental models including total cardiopulmonary bypass and isolated hindlimb perfusion)
Comparison
Inflation of the lungs to a positive pressure of… vs Baseline state and post-bilateral cervical…
Design
Preclinical
Authors
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May underlie hemodynamic responses to positive-pressure ventilation in dogs; leaves open translation to human critical care.
Does inflation of the lungs to a positive pressure of 20 mm Hg produce reflex cardiovascular depression in dogs?
Sudden expansion of the lungs in dogs activates a vagal depressor reflex causing negative inotropic and chronotropic responses and arterial vasodilation.
Glick et al. (1970) studied this question.
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