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June 1, 1997International Journal of Clinical PracticeOpen Access

European Stroke Prevention Study 2: Dipyridamole and Acetylsalicylic Acid in the Secondary Prevention of Stroke

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Why the study?

Does acetylsalicylic acid, modified-release dipyridamole, or their combination prevent stroke or death in patients with prior stroke or TIA?

Population

Patients with prior stroke or transient ischaemic attack (TIA)

Comparison

Acetylsalicylic acid 50 mg daily… vs Placebo

Design

RCT, randomised, double-blind

Follow-up

two years

Authors

CFCD ForbesNinewells Hospital

Discussion

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Overview

Combination therapy is superior for secondary prevention after stroke/TIA; confirms additive efficacy of dipyridamole plus ASA over monotherapy in RCT.

Structured PICO

Does acetylsalicylic acid, modified-release dipyridamole, or their combination prevent stroke or death in patients with prior stroke or TIA?

P
Population
Patients with prior stroke or transient ischaemic attack (TIA)
I
Intervention
Acetylsalicylic acid (ASA) 50 mg daily, modified-release dipyridamole 400 mg daily, or the two agents in a combined formulation (dipyridamole 200 mg b.d. and ASA 25 mg b.d.)
C
Comparator
Placebo
O
Outcome
Stroke, death, and stroke or deathhard clinical

The combination of dipyridamole and aspirin is significantly more effective than either agent alone for the secondary prevention of stroke and TIA.

Cite This Study

CD Forbes (1997) studied this question.

synapsesocial.com/papers/6a86f5ffc7caab105a154e89https://doi.org/10.1111/j.1742-1241.1997.tb11433.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1European Stroke Prevention Study. ESPS Group.1990 · 168 citations
  2. 2Antiplatelet agents in the secondary prevention of stroke: meta-analysis of the randomized control trials.1988 · 84 citations
  3. 3Dipyridamole alone or combined with low‐dose acetylsalicylic acid inhibits platelet aggregation in human whole blood ex vivo [see comments]1990 · 86 citations
  4. 4Acetylsalicylic acid in the prevention of stroke in patients with reversible cerebral ischemic attacks. A Danish cooperative study.1983 · 192 citations
  5. 5A randomized trial of aspirin and sulfinpyrazone in patients with TIA.1982 · 94 citations