Why the study?
Does combination therapy with aspirin and dipyridamole reduce the composite of vascular death, non-fatal myocardial infarction, and non-fatal stroke in patients with TIA or minor stroke compared to aspirin alone?
Population
7,612 patients with transient ischaemic attack or minor stroke of presumed arterial origin
Comparison
Combination therapy with aspirin and dipyridamole vs Aspirin alone
Design
Meta-analysis
Authors
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Supports aspirin-dipyridamole over aspirin alone for secondary prevention after TIA or minor stroke; confirms benefit on vascular events in meta-analysis.
Does combination therapy with aspirin and dipyridamole reduce the composite of vascular death, non-fatal myocardial infarction, and non-fatal stroke in patients with TIA or minor stroke compared to aspirin alone?
The combination of aspirin and dipyridamole is more effective than aspirin alone for secondary prevention of stroke and other vascular events in patients with TIA or minor stroke, independent of baseline risk.
Halkes et al. (2008) studied this question.
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