Why the study?
Does dipyridamole, given alone or with aspirin, reduce recurrent stroke and other vascular events in patients with previous ischemic stroke or TIA?
Population
11,459 patients with previous ischemic stroke or transient ischemic attack pooled from 5 randomized…
Comparison
Dipyridamole, given alone or combined with aspirin vs Control, aspirin alone, or dipyridamole alone
Design
Meta-analysis
Authors
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Supports combined aspirin-dipyridamole over aspirin alone for secondary prevention after ischemic stroke or TIA; strengthens pooled RCT evidence for dual antiplatelet therapy.
Does dipyridamole, given alone or with aspirin, reduce recurrent stroke and other vascular events in patients with previous ischemic stroke or TIA?
In patients with prior ischemic stroke or TIA, the combination of dipyridamole and aspirin significantly reduces recurrent stroke and composite vascular events compared to aspirin alone.
Leonardi‐Bee et al. (2004) studied this question.
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