September 1, 1998Neurology
Low-dose and high-dose acetylsalicyclic acid, with and without dipyridamole
Why the study?
Does aspirin alone or in combination with dipyridamole reduce the risk of vascular events in patients with prior stroke or TIA?
Population
Patients with a history of stroke or transient ischemic attack (TIA)
Comparison
Aspirin, dipyridamole, or their combination vs Placebo or aspirin alone
Design
Meta-analysis
Authors
Discussion
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Implication
Supports aspirin-dipyridamole over aspirin alone for secondary prevention after stroke/TIA; confirms and extends prior trial evidence.
Structured PICO
Does aspirin alone or in combination with dipyridamole reduce the risk of vascular events in patients with prior stroke or TIA?
P
Population
Patients with a history of stroke or transient ischemic attack (TIA)
I
Intervention
Aspirin (high 1,000-1,500 mg, medium 250-500 mg, and low 50-100 mg doses), dipyridamole, or their combination
C
Comparator
Placebo or aspirin alone
O
Outcome
Composite of stroke, myocardial infarction, and vascular death (vascular events)composite
The combination of dipyridamole and aspirin is more effective than aspirin alone for the secondary prevention of vascular events in patients with prior stroke or TIA.
Cite This Study
Jan G.P. Tijssen (1998) studied this question.