Why the study?
Does para-aminobenzoic acid inhibit N-acetylation of procainamide in healthy volunteers?
Population
11 healthy volunteers (7 female, 4 male) who are fast acetylators of caffeine
Comparison
Para-aminobenzoic acid 1.5 g orally every 6… vs Intravenous procainamide alone
Design
RCT, randomized, two-way crossover study
Follow-up
72 hours
Authors
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PABA unlikely to optimize procainamide therapy due to impaired NAPA clearance; confirms acetylation inhibition but extends to reduced renal elimination.
Does para-aminobenzoic acid inhibit N-acetylation of procainamide in healthy volunteers?
Although PABA inhibits the metabolic conversion of procainamide to NAPA, it also impairs NAPA renal clearance, suggesting it may not be clinically useful for optimizing procainamide therapy.
Tisdale et al. (1995) studied this question.