Key result
Chronic muscle denervation was associated with selective accumulation of sarcolemmal and sarcoplasmatic proteins in targetoid phenomena, with high colocalization of gamma-sarcoglycan and desmin.
Population
8 biopsies of patients with chronic denervation, mainly resulting from amyotrophic lateral sclerosis…
Design
Other
Authors
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May inform biopsy interpretation in denervating disorders; hypothesis-generating for dystrophin-associated protein trafficking.
Observational (n=8)
Selective changes in the expression of dystrophin-associated proteins occur during disturbed trafficking after chronic muscle denervation, suggesting complex molecular control.
Fellenberg et al. (2003) conducted an observational in Chronic denervation (amyotrophic lateral sclerosis) (n=8). Chronic muscle denervation was evaluated on Expression and colocalization of sarcolemmal and sarcoplasmatic proteins in targetoid phenomena. Chronic muscle denervation was associated with selective accumulation of sarcolemmal and sarcoplasmatic proteins in targetoid phenomena, with high colocalization of gamma-sarcoglycan and desmin.
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