Key result
A single-pill combination of amlodipine/atorvastatin plus TLC significantly increased dual blood pressure and LDL cholesterol goal attainment at week 4 compared with placebo (47.6% vs 1.7%; P<.001).
Why the study?
Does a single-pill combination of amlodipine and atorvastatin plus therapeutic lifestyle changes improve dual blood pressure and LDL cholesterol goal attainment in patients with comorbid hypertension and dyslipidemia?
RCT
double-blind
randomized
Yes
Does a single-pill combination of amlodipine and atorvastatin plus therapeutic lifestyle changes improve dual blood pressure and LDL cholesterol goal attainment in patients with comorbid hypertension and dyslipidemia?
Absolute Event Rate: 47.6% vs 1.7%
p-value: p=<.001
A single-pill combination of amlodipine and atorvastatin significantly improves the simultaneous achievement of blood pressure and LDL cholesterol targets in patients with hypertension and dyslipidemia.
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Supports single-pill amlodipine/atorvastatin plus TLC as initial therapy for comorbid hypertension and dyslipidemia; confirms rapid dual-goal attainment in this RCT.
Neutel et al. (2009) conducted an RCT in hypertension and dyslipidemia. amlodipine/atorvastatin plus therapeutic lifestyle changes vs. placebo plus therapeutic lifestyle changes was evaluated on proportion of patients in whom the dual goal of blood pressure (<140/90 mm Hg) and low-density lipoprotein cholesterol control (<100 mg/dL) was met at week 4 (p=<.001). A single-pill combination of amlodipine/atorvastatin plus TLC significantly increased dual blood pressure and LDL cholesterol goal attainment at week 4 compared with placebo (47.6% vs 1.7%; P<.001).
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