Key result
Alcohol consumption of ≥50 g per week was associated with a significantly lower rate of coronary restenosis after PTCA and stenting compared to <50 g per week (33.7% vs 48.8%, p=0.001; OR 0.54).
Why the study?
Does alcohol consumption of ≥ 50 g a week reduce restenosis and repeat angioplasty in male patients after PTCA and stent implantation?
Cohort (n=225)
Does alcohol consumption of ≥ 50 g a week reduce restenosis and repeat angioplasty in male patients after PTCA and stent implantation?
Moderate alcohol consumption (≥ 50 g/week) is associated with reduced angiographic restenosis and need for repeat angioplasty in men following PTCA and stenting.
Answers are grounded in this paper and cite their sources.
Moderate alcohol intake was associated with lower restenosis post-stenting in men; leaves open causation versus confounding and requires prospective confirmation.
OBJECTIVE: To disclose possible influences of alcoholic beverages on restenosis rate in men with coronary artery disease treated with percutaneous transluminal coronary angioplasty (PTCA) and stent implantation. DESIGN: Retrospective cohort study. PATIENTS: 225 consecutive male patients underwent PTCA and stent implantation. All patients had a control angiography and were contacted for a questionnaire regarding their drinking habits. MAIN OUTCOME MEASURES: Mean late loss of luminal diameter, rate of coronary restenosis of 50% or more within the stented segment, and rate of repeat angioplasty. RESULTS: 53 patients (with 80 stents) consumed < 50 g of alcohol a week and 172 (with 266 stents) consumed more (50-700 g a week). Baseline characteristics were similar in both groups except for a higher prevalence of reduced cardiac function and multivessel disease and a lower high density lipoprotein cholesterol concentration among patients who consumed little or no alcohol. Patients who consumed > or = 50 g alcohol a week had a lower mean late loss of the luminal diameter (1.1 (0.79) mm v 1.45 (0.82) mm, p = 0.002), a lower rate of coronary restenosis within the stented segment (33.7% v 48.8%, p = 0.001), and a lower rate of repeat angioplasty (23.3% v 42.5%, p = 0.002). In multivariate analysis, only alcohol consumption and diabetes were independent and significant discriminators for late loss of luminal diameter (p = 0.005 and p = 0.01, respectively), restenosis (odds ratio 0.54 and 2.08, respectively), and repeat angioplasty (odds ratio 0.39 and 2.18, respectively). CONCLUSION: Alcohol intake is associated with reduced restenosis after PTCA and stent implantation.
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Feraydoon Niroomand (2004) conducted a cohort in Coronary artery disease (n=225). Alcohol consumption ≥ 50 g a week vs. Alcohol consumption < 50 g a week was evaluated on Rate of coronary restenosis of 50% or more within the stented segment (OR 0.54, p=0.001). Alcohol consumption of ≥50 g per week was associated with a significantly lower rate of coronary restenosis after PTCA and stenting compared to <50 g per week (33.7% vs 48.8%, p=0.001; OR 0.54).
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