Key result
Larger pre-procedural mean platelet volume was associated with a significantly higher risk of angiographically defined restenosis after successful PTCA (OR 10.43, P<0.01).
Why the study?
Do pre-procedural haematological parameters predict angiographically defined restenosis in patients with stable angina undergoing successful PTCA?
Cohort (n=102)
Do pre-procedural haematological parameters predict angiographically defined restenosis in patients with stable angina undergoing successful PTCA?
Larger pre-procedural mean platelet volume is strongly associated with an increased risk of angiographic restenosis following successful PTCA in patients with stable angina.
Answers are grounded in this paper and cite their sources.
May support MPV as restenosis risk marker post-PTCA; leaves open prospective validation before clinical use.
OBJECTIVES: Restenosis is the major limitation of coronary interventions occurring in nearly a third of the patients undergoing percutaneous transluminal coronary angioplasty (PTCA) with no single, definite predictor demonstrated in an individual patient. Platelets are known to play an important role in the pathogenesis of subsequent restenosis. METHODS AND RESULTS: In a prospective study, follow-up coronary angiographies were performed in 102 consecutive patients with stable angina who underwent a successful PTCA for single-vessel coronary artery disease. Demographics, baseline lipid profiles (total cholesterol, HDL- and LDL-cholesterol, triglycerides) and haematological parameters (red cell, white cell and platelet counts, haemoglobin concentration, haematocrite %, mean platelet volume, platelet mass and fibrinogen levels) were compared between patients with and without restenosis. In the restenosis group, mean platelet volume (8.82 +/- 0.78 fl vs. 8.13 +/- 0.64 fl, p < 0.001), white cell count (8673 +/- 322 x 10(3)/microl vs. 7513 +/- 232 x 10(3)/microl, p < 0.01) and fibrinogen level (4.2 +/- 1.4 g/l vs 3.6 +/- 1.1 g/l) were significantly higher. The relative odds for developing angiographically defined restenosis were 2.49 times greater in diabetics (p = 0.11) and 2.54 times greater in men (p = 0.13). It is 1.43 times greater in patients with higher fibrinogen levels (p = 0.16). But, the relative odds for developing restenosis were 10.43 times greater in patients with larger pre-procedural mean platelet volumes (p < 0.01). CONCLUSIONS: There was a positive correlation between mean platelets volume and loss in luminal diameter between post-angioplasty and follow-up angiographies (r = +2.345, p = 0.01). There was no association between restenosis and haemoglobin, haematocrit, red cell count, white cell count, platelet count, platelet mass and plasma fibrinogen level. The development of restenosis after successful coronary angioplasty may be mainly influenced by the platelet size.
No takes yet. Share an insight, caveat, or question.
Avcı et al. (2004) conducted a cohort in Stable angina with single-vessel coronary artery disease post-PTCA (n=102). Larger pre-procedural mean platelet volume vs. Smaller pre-procedural mean platelet volume was evaluated on Angiographically defined restenosis (OR 10.43, p=<0.01). Larger pre-procedural mean platelet volume was associated with a significantly higher risk of angiographically defined restenosis after successful PTCA (OR 10.43, P<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: