Why the study?
Do insulin and IGF-I attenuate endothelin-induced contraction in porcine coronary epicardial arteries?
Population
Epicardial arteries harvested from juvenile pigs (with and without endothelium)
Comparison
Incubation with 10 M regular insulin or IGF-I… vs Endothelin-1 or sarafotoxin-6c without insulin…
Design
Preclinical
Authors
Loading...
Insulin/IGF-I modulation of porcine coronary ETA contraction may extend mechanistic insights; leaves open translation to human vasomotor disease or therapy.
Do insulin and IGF-I attenuate endothelin-induced contraction in porcine coronary epicardial arteries?
Insulin and IGF-I attenuate ETA-receptor-mediated coronary contraction through an endothelium-independent mechanism, suggesting the IGF axis may serve as an endogenous modulator of endothelin-mediated vasoconstriction.
David Hasdai (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: