Key result
The combination of gabapentin and ondansetron significantly increased the proportion of patients free from nausea at 15 minutes postoperatively compared to dexamethasone and ondansetron (86.8% vs 68.6%, p=0.026).
Why the study?
Existing combination drug guidelines have not effectively reduced the 40-90% incidence of PONV after general anesthesia, prompting evaluation of a gabapentin-ondansetron combination.
Does the combination of Gabapentin-Ondansetron reduce the incidence of Post Operative Nausea and Vomiting compared to Dexamethasone-Ondansetron in patients undergoing laparoscopic surgery?
RCT (n=73)
Double-blind
Randomized
No
Does the combination of Gabapentin-Ondansetron reduce the incidence of Post Operative Nausea and Vomiting compared to Dexamethasone-Ondansetron in patients undergoing laparoscopic surgery?
Absolute Event Rate: 86.8% vs 68.6%
p-value: p=0.026
The combination of Gabapentin-Ondansetron is more effective than Dexamethasone-Ondansetron for early postoperative nausea prophylaxis in laparoscopic surgery.
Gabapentin-ondansetron may outperform dexamethasone-ondansetron for PONV prophylaxis after laparoscopy; extends prior observational signals in an RCT.
Background: Post Operative Nausea and Vomiting (PONV) is a complication that most often occurs in patients undergoing surgery under general anesthesia, with an incidence rate of 40-90%. The existing combination drug guidelines to prevent PONV have not been effective in significantly reducing the incidence of PONV. There are several research results that suggest that the GabapentinOndansetron combination is effective in reducing the incidence of PONV. Objective: This study aims to compare the effectiveness of the combination of Gabapentin-Ondansetron with Dexamethasone-Ondansetron as a prophylactic of Post Operative Nausea and Vomiting (PONV) in laparoscopic surgery. Methods: This study is a double-blind Randomized Controlled Trial/RCT involving 78 patients who underwent a laparoscopic procedure. Subjects were divided into two groups A and B. Group A was given a combination of Gabapentin 600 mg and Ondansetron 0.1 mg/kgBW. Group B was given a combination of Dexamethasone 10 mg and Ondansetron 0.1 mg/kgBW. Both groups assessed the incidence of PONV using VNRS for nausea and assessed the presence or absence of vomiting. Results: At 15 and 30 minutes postoperatively, Gabapentin-Ondansetron was better than Dexamethasone-Ondansetron as a prophylactic of nausea (p <0.05) in laparoscopic surgery. At 60, 90, and 24 hours postoperatively, the drug combination of the two groups was as good as nausea prophylaxis (p >0.05) for laparoscopic surgery. Both of these drug combinations had the same effect as vomiting prophylaxis (p >0.05) after laparoscopic surgery. Conclusion: Gabapentin-Ondansetron combination is more effective thanDexamethasone-Ondansetron combination as a prophylactic of Post OperativeNausea and Vomiting (PONV) in laparoscopic surgery
No takes yet. Share an insight, caveat, or question.
Ridha et al. (2023) conducted an RCT in Postoperative Nausea and Vomiting (PONV) (n=73). Gabapentin and Ondansetron vs. Dexamethasone 10 mg IV and Ondansetron 0.1 mg/kgBW IV was evaluated on Proportion of patients free from nausea at 15 minutes postoperatively (p=0.026). The combination of gabapentin and ondansetron significantly increased the proportion of patients free from nausea at 15 minutes postoperatively compared to dexamethasone and ondansetron (86.8% vs 68.6%, p=0.026).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: