Why the study?
Postoperative nausea and vomiting is a major complication occurring in up to 70% to 80% of high-risk patients after elective surgery under general anesthesia, making its prevention or reduction a major goal.
Does intravenous ondansetron plus dexamethasone reduce postoperative nausea and vomiting in patients undergoing elective surgeries under general anesthesia compared to ondansetron alone?
Population
100 patients undergoing elective surgeries under general anesthesia
Comparison
Intravenous ondansetron 4mg plus dexamethasone 8mg vs intravenous ondansetron 4mg alone
Design
Randomized study
Follow-up
24 hours
Authors
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May support ondansetron-dexamethasone combination for PONV; leaves open need for confirmatory RCTs before practice change.
Does intravenous ondansetron plus dexamethasone reduce postoperative nausea and vomiting in patients undergoing elective surgeries under general anesthesia compared to ondansetron alone?
The combination of intravenous ondansetron and dexamethasone is superior to ondansetron alone in controlling postoperative nausea and vomiting, particularly delayed vomiting, after elective surgeries under general anesthesia.
Reddy et al. (2020) studied this question.
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