Key result
Combination ondansetron and dexamethasone yielded an 84% complete response (no nausea/emesis) postoperatively, compared to 52% with ondansetron alone and 60% with dexamethasone alone.
Why the study?
Does the combination of ondansetron and dexamethasone prevent postoperative nausea and vomiting in patients undergoing major elective gynecologic surgery?
Population
Patients undergoing major elective gynecologic surgery
Comparison
Combination of ondansetron and dexamethasone vs Ondansetron alone or dexamethasone alone
Design
Editorial
Follow-up
48 hours
Authors
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The combination of ondansetron and dexamethasone is highly effective and superior to either agent alone for preventing postoperative nausea and vomiting in major gynecologic surgery.
Does the combination of ondansetron and dexamethasone prevent postoperative nausea and vomiting in patients undergoing major elective gynecologic surgery?
Absolute Event Rate: 84% vs 52%
The combination of ondansetron and dexamethasone is highly effective and superior to either agent alone for preventing postoperative nausea and vomiting in major gynecologic surgery.
PEZ-OIAONDO et al. (1997) conducted an editorial in Postoperative nausea and vomiting. Combination ondansetron and dexamethasone vs. Ondansetron alone or dexamethasone alone was evaluated on No nausea and no emetic episodes during the 48-hr postoperative period. Combination ondansetron and dexamethasone yielded an 84% complete response (no nausea/emesis) postoperatively, compared to 52% with ondansetron alone and 60% with dexamethasone alone.
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