Key result
Ondansetron plus dexamethasone increased the complete response rate compared to ondansetron plus saline (52% vs 38%, P=0.048) for preventing postoperative nausea and vomiting.
Why the study?
Does intravenous ondansetron plus dexamethasone improve the prevention of postoperative nausea and vomiting compared to ondansetron alone in women undergoing major gynecologic surgery?
Population
180 women having general anesthesia for major gynecologic surgery
Comparison
Intravenous ondansetron 4 mg plus dexamethasone… vs Intravenous ondansetron 4 mg plus saline during…
Design
RCT, randomized, double-blind
Follow-up
24 hours
Authors
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Supports adding dexamethasone to ondansetron for PONV prophylaxis in gynecologic surgery; confirms efficacy of combination antiemetics.
RCT (n=180)
Double-blind
Randomized
Does intravenous ondansetron plus dexamethasone improve the prevention of postoperative nausea and vomiting compared to ondansetron alone in women undergoing major gynecologic surgery?
Absolute Event Rate: 52% vs 38%
p-value: p=0.048
The combination of ondansetron and dexamethasone is more effective than ondansetron alone for preventing postoperative nausea and vomiting in women undergoing major gynecologic surgery.
McKenzie et al. (1994) conducted an RCT in Postoperative nausea and vomiting (n=180). Ondansetron plus dexamethasone vs. Intravenous ondansetron 4 mg plus saline was evaluated on Complete response (no emesis and no need for rescue antiemetic during the 24-h postoperative period) (p=0.048). Ondansetron plus dexamethasone increased the complete response rate compared to ondansetron plus saline (52% vs 38%, P=0.048) for preventing postoperative nausea and vomiting.
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