Key result
Sarcoplasmic reticulum Ca2+ release decreased total Ca2+ influx during the action potential by approximately 50%, which was unaltered by temperature (6.0 vs 5.6 micromol/L cytosol).
Population
Isolated rabbit ventricular myocytes
Comparison
Action potential clamp at 25 degrees C and 35… vs Comparison between 25 degrees C and 35 degrees…
Design
Preclinical
Authors
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Should not change clinical Ca2+ management assumptions; hypothesis-generating for excitation-contraction coupling in mammalian models.
Absolute Event Rate: 6% vs 5.6%
Sarcoplasmic reticulum Ca2+ release decreases Ca2+ influx during the action potential by approximately 50% in rabbit ventricular myocytes, independent of temperature.
Puglisi et al. (1999) studied this question. Temperature 35 degrees C vs. Temperature 25 degrees C was evaluated on Total Ca2+ influx via I(Ca) during the action potential in steady state. Sarcoplasmic reticulum Ca2+ release decreased total Ca2+ influx during the action potential by approximately 50%, which was unaltered by temperature (6.0 vs 5.6 micromol/L cytosol).
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