Key result
Contrast-enhanced ultrasound revealed specific imaging characteristics that provided valuable clues for the diagnosis of primary hepatic angiosarcoma and guided successful puncture biopsy.
Why the study?
Primary hepatic angiosarcoma is a rare malignant tumor whose clinical manifestations, laboratory, and imaging examinations often lack specificity.
Case Report (n=1)
No
Contrast-enhanced ultrasound can provide valuable diagnostic clues for primary hepatic angiosarcoma and improve the success rate of puncture biopsy.
May raise suspicion for PHA via ultrasound and labs; hypothesis-generating, needs validation in larger cohorts.
BACKGROUND: Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of the vascular endothelium. Clinical manifestations and laboratory and imaging examinations often lack specificity for PHA. We report a case of PHA, and describe the ultrasound characteristics and characteristic changes in laboratory values associated with PHA. CASE SUMMARY: A 75-year-old woman presented with right upper quadrant abdominal pain for half a month. Magnetic resonance imaging (MRI) at a local hospital revealed multiple liver space-occupying lesions, and she was admitted to our hospital for further diagnosis. Contrast-enhanced ultrasound (CEUS) revealed multiple slightly hyperechoic nodules in the liver, which were suspected to be of malignant vascular origin. Contrast-enhanced computed tomography revealed multiple low-density nodules in the liver, considered to be metastatic hematopoietic malignancies. Contrast-enhanced MRI showed that the multiple liver nodules shared features with infectious lesions. Laboratory examination revealed normal alpha-fetoprotein levels, slightly increased other liver enzymes, decreased platelets, and significantly increased D-dimer levels. Liver biopsy and histopathology confirmed the presence of PHA. CONCLUSION: CEUS can provide valuable clues for the diagnosis of PHA and greatly improve the success rate of puncture biopsy.
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Wang et al. (2022) conducted a case report in Primary hepatic angiosarcoma (n=1). Contrast-enhanced ultrasound (CEUS) was evaluated on Diagnosis of primary hepatic angiosarcoma. Contrast-enhanced ultrasound revealed specific imaging characteristics that provided valuable clues for the diagnosis of primary hepatic angiosarcoma and guided successful puncture biopsy.
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