Why the study?
Does renovascular hypertension alter the expression of ventricular myosin light chain 1 (RVMLC1) in rat hearts?
Population
Rat hearts, including a renovascular hypertension model induced by unilateral renal artery clipping.
Comparison
Renovascular hypertension vs Normotensive clipped controls
Design
Preclinical
Follow-up
2 days or 2-3 weeks
Authors
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RVMLC1 mRNA stability in hypertensive rat hearts cautions against its use as remodeling marker; extends dissociation from MHC isoform switching.
Does renovascular hypertension alter the expression of ventricular myosin light chain 1 (RVMLC1) in rat hearts?
Ventricular myosin light chain 1 (RVMLC1) is developmentally regulated but, unlike myosin heavy chain isoforms, its expression is not altered by renovascular hypertension in rats.
McNally et al. (1989) studied this question.
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