Population
Scallop heavy meromyosin
Comparison
Presence of Ca2+ vs Absence of Ca2+
Design
Preclinical
Authors
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Ca2+-dependent product release kinetics support myosin regulation models; leaves open applicability to mammalian cardiac muscle.
Ca2+ controls the rate of conformational changes at the active site of scallop heavy meromyosin, with kinetic trapping of nucleotides and Pi in the absence of Ca2+ suppressing interaction with thin filaments.
Jackson et al. (1988) studied this question.
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